Protective Effects of Active Ingredients of Notoginseng on Immunological Liver Injury
10.3969/j.issn.0253-9896.2014.09.011
- VernacularTitle:三七有效成分对免疫性肝损伤的保护作用
- Author:
Wei WEI
;
Yongzhi HUANG
;
Liudan LIANG
;
Fengying NONG
;
Chaopeng NONG
;
Tao LI
- Publication Type:Journal Article
- Keywords:
sanchinoside;
BCG vaccine;
lipopolysaccharides;
total flavonoids;
polysaccharide;
immune liver injury
- From:
Tianjin Medical Journal
2014;(9):893-895
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of active components of notoginseng on immunological liver injury in mice. Methods Sixty Kunming mice were randomly divided into normal group (group A), model group (Group B), PNS group (Group C), total flavonoids group (Group D),and polysaccharide group (group E). C,D and E groups were given PNS, total flavonoids and polysaccharide orally, 1/day for 14 days. Then BCG was intravenous injected in B, C, D and E groups, and after 26 days lipopolysaccharide (LPS) was intravenous injected. Samples of eye venous plexus blood were collected, and serum levels of alanine aminotransferase (ALT), total superoxide dismutase (T-SOD) and Interleukin-4 (IL-4) were detected. Organs index was calculated by checking pathological results of liver, spleen and thymus. Results Com-pared with group B, the thymus index and serum ALT levels were significantly decreased in C, D and E groups (P<0.01), but the levels of IL-4 and T-SOD increased significantly (P<0.01). Pathological results showed that there were more serious inflammatory cell infiltration in liver, edema and necrosis of dot in C, D and E groups than those in group B. Conclusion The active components of notoginseng showed a significant protective effect on immunological liver injury.
