The Relationship between Homocysteine and Carotid Intima-Media Thickness in Patients with Brain Infarction
10.3969/j.issn.0253-9896.2014.09.013
- VernacularTitle:脑梗死患者同型半胱氨酸与颈动脉内膜中层厚度的关系
- Author:
Yu WANG
;
Zhecheng ZHANG
;
Ju ZHU
;
Jing ZHANG
;
Suhong WANG
;
Fengyan JIN
;
Xinzhong YANG
;
Li TIAN
- Publication Type:Journal Article
- Keywords:
hyperhomocysteinemia;
brain infarction;
carotid arteries;
atherosclerosis;
ultrasonography,doppler;
folic acid;
vitamin B12;
carotid intima-media thickness
- From:
Tianjin Medical Journal
2014;(9):899-902
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between total homocysteine (tHcy) and carotid intima-media thickness (CIMT) in brain infarction patients. Methods Sixty patients with fasting plasma tHcy levels ≤10μmol/L (non-Hhcy group), 60 patients with fasting plasma tHcy levels>10μmol/L and≤15μmol/L (H1 group), and 60 patients with fast-ing plasma tHcy levels>15μmol/L (H2 group) were chosen in hospitalized patients with acute cerebral infarction. Values of CIMT were detected in three groups of patients. The clinical biochemical indicators including triglyceride (TG), total choles-terol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood sugar (FBS), folic acid (FA), Vitamin B12 (VitB12) and glycated hemoglobin (HbA1c) were also detected. Results There was signifi-cant difference in CIMT between three groups (P<0.01). The value of CIMT increased in H2 group [0.98(0.90, 1.05)mm] com-pared with that of non-Hhcy group [0.85(0.80, 0.95)mm]. The value of CIMT increased in H2 group compared with H1 group [0.98(0.90, 1.05)mm vs 0.85(0.85, 0.95)mm], P<0.05). There were significant differences in tHcy, FA and VitB12 between three groups. Based on the log-transformed values of CIMT as the dependent variable, multiple stepwise linear regression showed significant associations of the following variables with increased CIMT: increasing age, the history of smoking, the history of diabetes, higher LDL-C and tHcy levels. Conclusion Brain infarction in patients with higher tHcy level often have lower levels of FA and VitB12, and increased CIMT. When the level of tHcy >15 μmol/L, there is more significantly higher level of CIMT. The increased CIMT level was associated with some cerebrovascular risk factors in patients with brain infarction.
