Expression and Clinic Significance of Serum DJ-1 in Ovarian Cancer
10.3969/j.issn.0253-9896.2014.09.019
- VernacularTitle:DJ-1蛋白在卵巢癌患者血清中的表达水平及意义
- Author:
Hui LIU
;
Weiming WANG
;
Zhihui CAI
;
Qun ZUO
;
Jin LIU
;
Shufang LIU
;
Yuping DONG
;
Xiaofang LU
- Publication Type:Journal Article
- Keywords:
ovarian neoplasms;
carcinoma;
DJ-1
- From:
Tianjin Medical Journal
2014;(9):920-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate serum DJ-1 expression and its significance in ovarian cancer. Methods The expression levels of DJ-1 protein were detected by double antibody sandwich method in 52 cases of ovarian tumors (9 cases of benign ovarian tumors, 5 cases of borderline ovarian tumors and 38 cases of ovarian cancer,ovarian tumor group and 20 non-ovarian tumors (control group). Results The expression of DJ-1 protein was lower in the control group than that in ovarian tumor group (P<0.05). The expression of serum DJ-1 protein was higher in ovarian cancer than that in borderline ovarian tumors and in benign ovarian tumors. The expression of serum DJ-1 protein was higher in borderline ovarian tumors than that in benign ovarian tumors (P<0.05).The expression of serum DJ-1 protein was higher in poorly differentiated and moderately differentiated ovarian cancer than that in high-grade differentiated ovarian cancer (P<0.05). No significant dif-ference was found in the expression serum of DJ-1 protein between different pathological and different histological types of ovarian cancer (P>0.05). Conclusion DJ-1 might be used as a serum marker in the diagnosis of ovarian cancer. It might be involved in the pathogenesis of ovarian cancer,and could predit the development and prognosis of ovarian cancer.
