Recent Advances on Vasohibin Family Regulating Angiogenesis
10.3969/j.issn.0253-9896.2014.09.029
- VernacularTitle:血管生成负反馈调节因子Vasohibin家族研究进展
- Author:
Ganggang SHI
;
Jianchen GAN
- Publication Type:Journal Article
- Keywords:
neovascularization,pathologic;
endothelial cells;
review;
angiogenesis;
vasohibin
- From:
Tianjin Medical Journal
2014;(9):949-952
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. Vasohibin family as a novel regulator of angiogenesis involves in the process of various pathophysiology. Vasohibin-1 is the only factor that regulates angiogenesis by means of negative feedback as the mechanism of action. It is expressed in ECs to terminate an-giogenesis. Subsequently one gene homologous to vasohibin-1 was found and designated as vasohibin-2, which is expressed in infiltrating MNCs or cancer cells to stimulate angiogenesis. Furthermore, one binding protein to vasohibin-1 and vasohib-in-2 has been discovered and renamed as small vasohibin-binding protein (SVBP). The analysis of the function of SVBP has revealed that SVBP binds to vasohibin-1 within cells, makes a heterodimer with vasohibin-1 and facilitates the secretion of vasohibin-1. This article reviews the construction features and biological activities of vasohibin family members and their ef-fects of inhibiting pathology angiogenesis.
