Serum metabolic profiles among different geographical populations
10.7644/j.issn.1674-9960.2014.08.016
- VernacularTitle:不同地域人群血清代谢谱分析
- Author:
Ruili CAO
;
Jingli GUO
;
Bo SUN
;
Qi ZHANG
;
Zheng YANG
;
Xianzhong YAN
- Publication Type:Journal Article
- Keywords:
metabonomics;
serum;
NMR;
geographical differences;
nutrition
- From:
Military Medical Sciences
2014;(8):633-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of geographical differences on human serum metabolic profiles .Methods A total of 169 serum samples were collected from healthy individuals from 9 provinces in China and divided into four groups according to the geographical location .The nuclear magnetic resonance ( NMR) data of these samples were segmentally inte-grated, normalized,and analyzed with multivariate statistical methods using SIMCA-P 10.0 software to investigate the differ-ence in serum metabolites between eastern and western populations or between northern and southern populations .Results There were differences in a variety of small molecule metabolites in serum between eastern and western populations or be -tween northern and southern,including glucose,lipoproteins,amino acids,ketones,creatine and choline.Conclusion The geographical differences in a variety of factors (temperature,precipitation,folk culture, living habits,etc) result in the differences in human serum metabolic profiles ,which can provide appropriate reference for epidemiological studies and nu -tritional metabonomics .
