Relationship between early serum creatinine level and respiratory failure in patients with acute paraquat poisoning
10.7644/j.issn.1674-9960.2014.08.018
- VernacularTitle:急性口服百草枯中毒患者早期血清肌酐值的变化与呼吸衰竭的关系
- Author:
Xiaoxia LU
;
Haochun WANG
- Publication Type:Journal Article
- Keywords:
paraquat;
poisoning;
serum creatinine;
respiratory failure
- From:
Military Medical Sciences
2014;(8):642-644
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively review the clinical data of acute oral paraquat (PQ) poisoning patients and the relationship of early serum creatinine leveles with respiratory failure , to predict and guide the clinical diagnosis and treatment .Methods Seventy-two PQ poisoning patients from the 2008 to 2012 , according to the occurrence of respiratory failure were divided into two groups , group A:patients with respiratory failure (28 cases);and group B:patients without respiratory failure(44 cases).The first serum creatinine detection early after poisoning as the basic value and the highest value within 48 hours, and the difference between the two ratios was compared .Then the sensitivity, specificity, accuracy, Youden index, receiver operating characteristic(ROC) area under the curve(AUC) were also calculated, and the ROC AUC was drawn.Results The creatinine basic value ,the highest valve and their ratio were obtained , and the difference was statistically significant .The best predictor boarder of creatinine basic value was 53 μmol/L, with forecasting moderate effect,and that of the highest value ,their ratio and the creatinine difference value was 183μmol/L, 3.39 and 113μmol/L, respectively.Conclusion The higher the early serum creatinine level rises , the higher the risk of respiratory failure increa-ses after PQ poisoning .The basic value , the highest value within 48 hours and their difference and ratio could predict the possibility of respiratory failure after PQ intoxication .
