Changes and significance of serum IL-6 in cancer patients with T2DM before and after chemotherapy
10.7644/j.issn.1674-9960.2014.08.019
- VernacularTitle:合并2型糖尿病恶性肿瘤患者化疗前后血清IL-6的表达变化
- Author:
Ye PENG
;
Xugang ZHANG
;
Xiufang YANG
;
Yichao HAN
;
Huimin ZHOU
;
Jie HU
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type 2;
malignant tumor;
chemotherapy;
immunosuppressive factor;
serum;
IL-6
- From:
Military Medical Sciences
2014;(8):645-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of chemotherapy on serum IL-6 expression in cancer patients with T2DM. Methods Eighty patients were divided into the malignant tumor group with T 2DM (n=40) and the malignant tumor group without T2DM (n=40).All the patients were given two cycles of chemotherapy .2 ml of fasting venous blood in the morn-ing before and after the day of chemotherapy was collected .Then the serum was separated .Enzyme-linked immunosorbent assay (ELISA)was used to measure the level changes of serum IL-6.20 cases of healthy people were selected for compari-son.Results The expression of serum IL-6 in groups with or without T2DM was significantly higher than in the normal control group before the first cycle of chemotherapy (P<0.05).The expression of serum IL-6 was decreased in the different-cancer group with T2DM after the first cycle of chemotherapy .But the level was increased after the second cycle of chemo-therapy (P<0.05).The expression of serum IL-6 showed a continuous decrease after the first and the second cycle of chemotherapy in the group without T2DM(P<0.05),but there was no significant difference between the two groups (P>0.05).Conclusion The expression level of serum IL-6 declines after the first cycle chemotherapy in the malignant tumor groups with T2DM or without T2DM but rises in the malignant tumor group with T2DM after the second cycle chemotherapy .
