Transcatheter thrombus-breaking combined with local infusion of reteplase for the treatment of severe pulmonary thromboembolism
10.3969/j.issn.1008-794X.2014.10.008
- VernacularTitle:导管碎栓联合局部灌注瑞替普酶溶栓治疗高危肺动脉栓塞
- Author:
Jinwen SONG
;
Zhihong WANG
;
Xinlin WANG
;
Jingguo ZHANG
;
Xuan WEI
;
Caixia LIU
- Publication Type:Journal Article
- Keywords:
severe pulmonary embolism;
reteplase;
pulmonary artery;
thrombolysis
- From:
Journal of Interventional Radiology
2014;23(10):870-873
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect and safety of transcatheter thrombus-breaking combined with local infusion of reteplase (rPA) in treating severe pulmonary thromboembolism (PTE). Methods During the period from June 2010 to June 2013 at authors’ hospital, transcatheter thrombus-breaking combined with local infusion of reteplase was carried out in 26 patients (17 males and 9 females) with severe pulmonary embolism. The changes of pulmonary circulation and the cardio - pulmonary hemodynamics after the treatment were analyzed. Results The preoperative mean pulmonary artery pressure, arterial blood oxygen partial pressure and the blood pressure were (63.78 ± 6.89) mmHg, (73.23 ± 11.51) mmHg and (87.35 ± 10.92) mmHg respectively, while the postoperative ones were (26.23 ± 10.27) mmHg, (93.48 ± 6.17) mmHg and(127.14 ± 13.15) mmHg respectively, and the differences between preoperative and postoperative ones were statistically significant (P<0.01). All the patients were followed up for 6 - 36 months. Significant stable clinical improvement was obtained in 25 patients, and recurrence was seen in one patient. Conclusion Transcatheter thrombus-breaking combined with local infusion of reteplase can quickly improve the pulmonary circulation and the clinical conditions for patients with severe pulmonary thromboembolism, and it has no obvious complications. This technique carries excellent value in maintaining the stability of hemodynamics.
