Biliary stenting combined with 125I seed implantation intracavitary irradiation for the treatment of malignant obstructive jaundice

Hongxiang Yao; Gensheng Chen; Guanxiong YE; Shengqian XU; Chengjun WU; Yong Qin; Debiao Pan; Qun Zeng; Ye Chen; Pengzhao Zhang

Return

Biliary stenting combined with 125I seed implantation intracavitary irradiation for the treatment of malignant obstructive jaundice

VernacularTitle:胆道支架联合125I粒子条治疗恶性梗阻性黄疸
Author: Hongxiang YAO ; Gensheng CHEN ; Guanxiong YE ; Shengqian XU ; Chengjun WU ; Yong QIN ; Debiao PAN ; Qun ZENG ; Ye CHEN ; Pengzhao ZHANG
Publication Type:Journal Article
Keywords: biliary stent; 125I seed; intracavitary irradiation; malignant obstructive jaundice
From: Journal of Interventional Radiology 2014;23(10):893-896
CountryChina
Language:Chinese
Abstract: Objective To discuss the method, safety and clinical value of biliary stenting combined with 125I seed implantation intracavitary irradiation in treating malignant obstructive jaundice. Methods A total of 36 patients with malignant obstructive jaundice were enrolled in this study. PTCD was carried out in all patients, which was followed by biliary stenting combined with 125I seed implantation intracavitary irradiation treatment. The results were analyzed. Results During the interventional management, displacement of the stent and 125I seeds were observed in two cases, and the displaced stent and 125I seeds were replaced to the right position with the help of biliary biopsy forceps. The technical success rate was 100%, and the remission rate of the jaundice was 100%. All the patients were followed up for 1-23 months. No radioactive particles leaking or complications such as radiation enteritis occurred. No in-stent obstruction due to tumor recurrence was observed although slight dilatation of intrahepatic bile duct was detected in 25%of patients, which was resulted from intimal hyperplasia at the stent mesh and/or biliary stone formation. The median survival time was 10.9 months. Conclusion For the treatment of malignant obstructive jaundice, biliary stenting combined with 125I seed implantation intracavitary irradiation is safe, reliable and effective. This technique can prolong stent patency time as well as the patient’s survival time.