Clinical significance of combined detection of three tumor markers in the diagnosis of non-small cell lung cancer
10.3969/j.issn.1673-4130.2015.13.032
- VernacularTitle:3种肿瘤标志物联合检测对非小细胞肺癌诊断的临床应用价值
- Author:
Xiaonan ZHANG
;
Xiangzhen LU
;
Yongqian YAN
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
lysophosphatidic acid;
tumor-specific growth factor;
carbohydrate antigen 1 9-9
- From:
International Journal of Laboratory Medicine
2015;(13):1876-1877
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of combined detection of lysophosphatidic acid(LPA),tumor-specific growth factor(TSGF)and carbohydrate antigen 1 9-9(CA1 9-9)in the diagnosis of non-small cell lung cancer(NSCLC).Methods The ser-um levels of LPA,TSGF and CA1 9-9 in 97 cases of patients with NSCLC(NSCLC group),43 cases of patients with benign lung disease(benign lung disease group)and 50 cases of healthy individuals(healthy control group)were detected,and diagnostic value of combined detection of these three tumor makers in the diagnosis of NSCLC was analysed.Results Serum levels of LPA,TSGF and CA1 9-9 in the NSCLC group were significantly higher than those in the benign lung disease group and healthy control group,had statistically significant differences(P <0.05).The sensitivity and specificity of combined detection of LPA,TSGF and CA1 9-9 was 68.63% and 37.1 7% respectively,and the sensitivity was higher than that of single detection and combined detection of any two of the three indicators.Conclusion Combined detection of tumor markers can improve the sensitivity in the diagnosis of NSCLC, which could provide reliable laboratory references for diagnosing NSCLC.
