Effect analysis on radiotherapy combined with zoledronic acid in treatment of bone metastasis of non-small cell lung cancer and influencing factors
10.3969/j.issn.1671-8348.2015.12.014
- VernacularTitle:放疗联合唑来膦酸治疗NSCLC骨转移的疗效分析及影响因素
- Author:
Jian LI
;
Ge WANG
;
He XIAO
;
Feng JIN
;
Xian YU
;
Bijing MAO
;
Rong HE
;
Mei JIANG
;
Zhenzhou YANG
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
carcinoma;
non-small-cell lung cancer;
bone;
neoplasm metastasis;
zoledronic acid;
radiotherapy
- From:
Chongqing Medicine
2015;44(12):1629-1632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the short-term efficacy and the influencing factorof zoledroniacid combined with ra-diotherapy and single radiotherapy in the treatmenof bone metastasiin non-small cell lung cance(NSCL) .MethodTotally 117 NSCLpatientwith bone metastase(153 lesions) receiving the bone lesion radiotherapy in the TumoCenteof ouhospital from 2009 to 2013 were selected and treated by zoledroniacid combined with radiotherapy (combined therapy group ,n=54) and the single radiotherapy (single radiotherapy group ,n=63) .The bone pain relief and influence factorwere analyzed .ResultThe effective ratein the single radiotherapy group and the combined radiotherapy group were 69 .74% and 92 .21% respectively (χ2 =13 .75 ,P＜0 .01);the multivariate Logistiregression analysishowed thathe bone pain relief wacorrelated with the treatmenmode ,moreovethe bone pain relief rate in the combined therapy group wasignificantly highethan thain the single therapy group (OR=4 .60 ,95% CI:1 .23-17 .20 ,P=0 .02) .In the subgroup analysiof treatmenmode,the patientwith osteolytile-sions(OR=26 .59 ,95% CI:3 .29-215 .12 ,P=0 .00) had betteeffec.The combined therapy group had more superiority in the as-pecof non-skeletal related eventoccurrence (OR=4 .40 ,95% CI:1 .49 -12 .99 ,P=0 .01) .Conclusion Radiotherapy combined with zoledroniacid habettecurative effeccompared with single radiotherapy in the NSCLC patientwith bone metastasi.
