Clinical significance of combined detection of procalcitonin and C reactive protein for guiding antibacterial agents use in patientls with pulmonary disease
10.3969/j.issn.1673-4130.2015.13.046
- VernacularTitle:血清降钙素原和C反应蛋白联合检测指导肺部疾病患者抗菌药物应用的临床意义
- Author:
Ming LUO
;
Liping WANG
;
Chunmei YUAN
;
Xiaomian SUN
;
Jian WANG
;
Zhixun WU
;
Yan JIANG
;
Hong CHEN
- Publication Type:Journal Article
- Keywords:
pulmonary disease;
procalcitonin;
C reactive protein;
antibacterials
- From:
International Journal of Laboratory Medicine
2015;(13):1913-1914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of combined detection of procalcitonin(PCT)and C reactive protein(CRP)for clinical use of antibacterial agents in patients with pulmonary disease.Methods 130 cases of patients with pulmonary disease,from October 2012 to October 2014,were selected and randomly dividend into the observation group and control group,65 cases in each group.In the observation group,the utilization of antibacterial agents was decided according to serum levels of PCT and CRP,while in the control group that was based on the white blood cell count.Observation indexes,such as utilization of antibacterial agents, curative efficiency,length of stay and so on,were compared between the two groups after treatment.Results The length of antibac-terial agents use in the observation group[(8.6±0.4)d]was longer than that in the control group[(1 6.2±2.3)d],had statistically significant difference(P <0.05 ).After treatment,there were no statistically significant differences in the white blood cell count, scores of pulmonary functional status,percentage of patients in aggravating stages and mortality between the two groups (P >0.05).While compared with the control group,the dual infection rate and length of stay decreased in the observation group,had sta-tistically significant difference(P <0.05).Conclusion Combined detection of PCT and CRP could guide the rational use of antibac-terial agents,effectively prevent the dual infection,and improve clinical curative effect.
