Study on Changes of IR and Myocardial Tissues Rat Model with Congestive Heart Failure Pathology by Yi-Qi Wen-Yang and Huo-Xue Li-Shui Decoction
10.11842/wst.2014.10.017
- VernacularTitle:益气温阳、活血利水方药对充血性心力衰竭大鼠模型IR及心肌组织病理学改变的研究
- Author:
Yaoyao WANG
;
Yunzhi CHEN
- Publication Type:Journal Article
- Keywords:
Yi-Qi Wen-Yang;
Huo-Xue Li-Shui;
IR;
pathological change of myocardium
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(10):2157-2161
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the effect of Yi-Qi Wen-Yang (YQWY) and Huo-Xue Li-Shui (HXLS) decoction on changes of insulin resistance (IR) model and the myocardial tissues of rats with congestive heart failure (CHF) pathology. CHF rat models were established on Wistar male rats through injection of doxorubicin hydrochlo-ride into rat tail vein. Wistar male rats models were randomly divided into the model group, western medicine group, low dose decoction group, middle dose decoction group, and high dose decoction group. After 4-week gavage, 3 mL vein blood was taken from the angular vein sinus for the determination of blood glucose and serum insulin, and the calculation of IR. Finally, the rats were sacrificed. And then, the heart was removed to make HE slice and observe the pathological change of myocardium. The results showed that compared with the model group, YQWY and HXLS decoction can improve the IR level among CHF rats (P<0.05). Among them, the effects of the high dose and middle dose group were obvious. At the same time, this decoction can improve the myocardial cells in CHF rats in myocar-dial cells of the high dose group. And its morphology change was close to the digoxin group. It was concluded that YQWY and HXLS decoction can reverse IR and improve ventricular remodeling among CHF rats to a certain extent.
