Studies on Stability of Hesperidin in Alkaline Solution

VernacularTitle:橙皮苷在碱性溶液中的稳定性研究
Author: Yumei HU ; Zhaoqing MENG ; Shan ZHANG ; Ningbo CHENG ; Gang DING ; Zhenzhong WANG ; Wei XIAO
Publication Type:Journal Article
Keywords: Hesperidin; stability; HPLC; degradation product
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(10):2270-2273
CountryChina
Language:Chinese
Abstract: This article was aimed to study the stability of hesperidin in alkaline solution, in order to provide experi-ment evidences for quality control of extraction and purification as well as formulation development. RP-HPLC was applied to determinate content changes of hesperidin in alkaline solution by changing the temperature, pH and heat-ing time. The results showed that hesperidin was degraded in alkaline solution by heating. The content of hesperidin decreased along with the increasing of heating temperature and heating time. The hesperidin appeared to be more stable in a weak base. It was concluded that for the purpose of ensuring of the stability of hesperidin in alkaline so-lution, it should be kept at low temperature (below 50℃), weak base conditions and shorten the heating time during the preparation process.