Effect and Action Mechanism of Resveratrol on Steroid-induced Diabetes Mellitus in Rats
10.11842/wst.2014.10.015
- VernacularTitle:白芦藜醇对大鼠类固醇糖尿病的影响及其作用机制研究
- Author:
Xiaoyan ZHOU
;
Changjiang YING
- Publication Type:Journal Article
- Keywords:
Resveratrol;
SDM;
blood sugar;
insulin resistance;
cell apoptosis;
TNF-α
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(10):2149-2152
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the effect of resveratrol on steroid-induced diabetes mellitus (SDM) in rats and the related mechanism. SD rats were randomly divided into the normal control (NC) group, SDM group, low dosage of resveratrol (LDR) group, middle dosage of resveratrol (MDR) group, and high dosage of resveratrol (HDR) group. All groups were tested on the change of blood glucose, insulin resistance (IR), adiponectin and tumor necrosis factor-α(TNF-α) in serum. The rate of cellular apoptosis in pancreas islet and the expression of BCL2 in rats were also observed. The results showed that compared with the SDM group, the blood sugar, IR, TNF-αlevel, and the ratio of pancreas islet cellular apoptosis in serum of the MR group and HDR group were lower (P<0.05). The expres-sion of adiponectin and BCL2 protein were up-regulated in the MR group and HDR group (P<0.05). It was conclud-ed that resveratrol can protect rats against the injury from MDR and HDR of SDM. This protective effect is possibly mediated by down-regulating the blood glucose, IR, inflammation factors in pancreas islet, and up-regulation of BCL2 protein, in order to inhibit cellular apoptosis in pancreas islet.
