Simultaneous Determination of Five Saponins in Yao-Bi-Tong Capsules by QAMS
10.11842/wst.2014.10.030
- VernacularTitle:“一测多评”法测定腰痹通胶囊中5种皂苷类成分的含量
- Author:
Baidong DAI
;
Liqiong SUN
;
Yanjing LI
;
Gang DING
;
Xin LI
;
Zhenzhong WANG
;
Yuan BI
;
Wei XIAO
- Publication Type:Journal Article
- Keywords:
QAMS;
relative correction factor;
ginsenosides;
notoginsenoside;
Yao-Bi-Tong capsules
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(10):2227-2232
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to establish a quality evaluation method, quantitative analysis of multi-components with a single-marker (QAMS) to determine the contents of five saponins in Yao-Bi-Tong (YBT) capsules. Ginseno-side Rg1 was used as the internal standard; the relative correction factor (RCF) of notoginsenoside R1, ginsenoside Re, ginsenoside Rb1 and ginsenoside Rd were calculated and evaluated. The contents of 5 saponins were determined by the external standard method and QAMS, respectively. Rationality, feasibility and repeatability of the QAMS method were verified by comparing the results obtained from two different methods. The results showed that RCFs of notoginsenoside R1, ginsenoside Re and ginsenoside Rb1 to ginsenoside Rg1 against YBT capsules were 0.999, 1.228, 0.990 and 1.094, respectively, indicating good reproducibility. These results of two methods had no significant dif-ference. It was concluded that the QAMS method can be accurately, rapidly and reasonably used as a new quality assessment model for ginsenosides in YBT capsules.
