The clonal origin of diffuse hepatocellular carcinoma
10.11958/j.issn.0253-9896.2015.05.013
- VernacularTitle:弥漫型肝细胞癌的克隆起源研究
- Author:
Luzhou ZHANG
;
Zhenglu WANG
;
Yuliang WANG
;
Hong ZHENG
- Publication Type:Journal Article
- Keywords:
carcinoma;
hepatocellular;
loss of heterozygosity;
liver transplantation;
diffuse hepatocellular carcinoma;
clonal origin
- From:
Tianjin Medical Journal
2015;43(5):496-499
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the tumor clonal origin of diffuse hepatocellular carcinoma (D-HCC) and clinical outcome after liver transplantation. Methods Fourteen D-HCC patients who underwent liver transplantation in the Tianjin First Central Hospital between August 2004 to November 2012 were evaluated retrospectively. Their clinical characteristics and data of disease-free survival postoperatively were gathered. Twelve loss of heterozygosity sites (LOH) on high frequency microsatellite were selected. The tumor clonal origin of D-HCC was assessed by the means of PCR-SSCP. Results Of 14 D-HCC patients, intrahepatic metastasis (IM) occurred in 11 cases (11/14), and IM with multicentric occurrence (MO) occurred in 3 cases (3/14). The disease-free survival time was 4.5 to 37.4 months, and the median time was 8.7 months. Conclusion The most frequent tumor clonal origin of D-HCC was IM. Liver transplantation may be the effective treatment for D-HCC.