A Rare Case of Free Bowel Perforation Associated with Infliximab Treatment for Stricturing Crohn's Disease.
10.4166/kjg.2013.62.3.169
- Author:
Chang Sup LIM
1
;
Won MOON
;
Seun Ja PARK
;
Moo In PARK
;
Hyung Hun KIM
;
Jong Bin KIM
;
Jeong Moon CHOI
;
Hee Kyung CHANG
;
Seung Hyun LEE
Author Information
1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. moonone70@hanmail.net
- Publication Type:Case Reports ; Review
- Keywords:
Crohn's disease;
Stricture;
Infliximab;
Perforation
- MeSH:
Adolescent;
Anti-Inflammatory Agents, Non-Steroidal/adverse effects/*therapeutic use;
Antibodies, Monoclonal/*adverse effects/*therapeutic use;
Colonoscopy;
Crohn Disease/*drug therapy;
Dietary Fiber;
Female;
Fibrosis/pathology;
Humans;
Ileum/surgery;
Intestinal Perforation/*chemically induced/surgery;
Tomography, X-Ray Computed
- From:The Korean Journal of Gastroenterology
2013;62(3):169-173
- CountryRepublic of Korea
- Language:English
-
Abstract:
Crohn's disease is characterized by chronic transmural inflammation of the bowel and is associated with serious complications, such as bowel strictures, abscesses, fistula formation, and perforation. As neither medical nor surgical therapy provides a cure for Crohn's disease, the primary goals of therapy are to induce and maintain remission and prevent complications. As a biologic agent, infliximab, a monoclonal antibody to tumor necrosis factor, is indicated for refractory luminal and fistulizing Crohn's disease that does not respond to other medical therapies or surgery. Infliximab has proven to be very effective for inducing and maintaining remission in Crohn's disease; however, infliximab treatment has several potential complications. Here, we report a case of free perforation following a therapeutic response after an initial dose of infliximab for Crohn's disease. This is the first case report describing a free perforation in a Crohn's disease patient after an initial dose of infliximab.
