Association between maternal MTHFR C677T polymorphism and neural tube defects in offsprings:a Meta-analysis

VernacularTitle:MTHFR基因C677T多态性与神经管缺陷相关性的Meta分析
Author: Yulian FANG ; Shikun MA ; Ouyan SHI ; Peng ZHANG ; Chunquan CAI
Publication Type:Journal Article
Keywords: neural tube defects; 5; 10-methylenetetrahydrofolate reductase (FADH2); polymorphism; genetic; Meta-analysis
From: Tianjin Medical Journal 2015;43(5):552-558
CountryChina
Language:Chinese
Abstract: Objective To explore the association between maternal methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and neural tube defects (NTDs). Methods CBM, VIP, CNKI, Wanfang, PubMed and Web of Science databases from set up to March, 2014 were electronically searched to identify case-control studies on the relationship between maternal MTHFR C677T polymorphism and NTDs. The data were quantitatively analyzed by RevMan 5.0 software. Results A total of 25 studies were selected including 2 282 cases and 3 420 controls. Overall, the pooled OR (with 95%CI) under co-dominant model and allele contrast were 2.28(1.60-3.24), 1.25(1.02-1.53) and 1.42(1.21-1.67). Subgroup analysis showed significant association between maternal MTHFR C677T polymorphism and NTDs susceptibility in Asian populations. Conclusion The present meta-analysis suggests that MTHFR C677T polymorphism is significantly associated with maternal risk for NTDs, especially in Asian populations.