Research progress of Nrf2/ARE pathway regulating mechanism
10.11958/j.issn.0253-9896.2015.05.032
- VernacularTitle:Nrf2/ARE通路调节机制的研究进展
- Author:
Xiaofang YI
;
Chao TAN
- Publication Type:Journal Article
- Keywords:
Nrf2;
Nrf2/ARE signal pathway;
oxidative stress
- From:
Tianjin Medical Journal
2015;43(5):573-575
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor E2 related factor Nrf2 is a nuclear transcription factors involved in a variety of protein expression. As a center of oxidative stress regulation, it combines with antioxidant components (antioxidant responsive element, ARE) and activates downstream multiple anti-oxidation, anti-inflammatory and detoxifying enzyme protein expression. This signaling pathway is involved in the development of inflammation, tumor and other pathological process. This review describes the basic structure, biological effects and signaling pathways of Nrf2, summarizes the latest progress about mechanisms of factors, which are involved in the positive and negative regulations of signal pathway, providing a new target for anti-inflammatory, antioxidant, and antitumor biochemical treatment. Based on these, the paper also looks forward to applicating bioinformatics technology and providing better prospects for the development of target intervention.
