The relationship between transcription factor NF-E2-related factor 2 and liver diseases
10.3760/cma.j.issn.2095-428X.2014.19.016
- VernacularTitle:转录因子NF-E2相关因子2与肝脏疾病的关系
- Author:
Li LIU
;
Shuangjie LI
- Publication Type:Journal Article
- Keywords:
Nuclear transcription factor NF-E2-related factor 2;
Oxidative stress;
Liver
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(19):1500-1502
- CountryChina
- Language:Chinese
-
Abstract:
The liver is the most exuberant organs of human metabolism,susceptible to oxidative stress injury.More and more studies in recent years show that various types of liver diseases such as hepatitis,liver fibrosis,liver cirrhosis,liver cancer and so on are closely related with oxidative stress injury.The transcription factor NF-E2-related factor 2 (Nrf2) is an important transcription factor regulating oxidative stress reaction.It combines with the antioxidant response element antioxidant response elements (ARE),then activates target gene transcription,and increases the resistance of cell to oxidative stress.Kelch-like ECH-associated protein 1-Nrf2-ARE pathway plays an important role in the pathogenesis of liver diseases.
