Influence Factors of Left Ventricular Hypertrophy in Incipient Lupus Nephritis Patients
10.11969/j.issn.1673-548X.2015.04.026
- VernacularTitle:初诊狼疮肾炎患者左心室肥厚的相关因素
- Author:
Xiaoqi SHEN
;
Weiqian CHEN
;
Jianghua CHEN
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
Lupus nephritis;
Left ventricular hypertrophy;
Cardiovascular disease
- From:
Journal of Medical Research
2015;44(4):97-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence factors of left ventricular hypertrophy ( LVH) in incipient systemic lupus erythe-matosus (SLE) patients with lupus nephritis (LN).Methods A total of 210 LN patients in the authors′centre were enrolled in this cross-section study .General information , laboratory measurements , examinations of left ventricular hypertrophy by ultrasonography were col -lected.Patients were divided into two groups according to left ventricular mass index (LVMI):left ventricle thickening (LVT) group (n=89) and left ventricle normal group (n=121).General information and laboratory results of two groups were statistically analyzed .In-fluence factors of the patients were analyzed with Spearman rank correlation and multiple linear regression .Results Serum uric acid and hyper-sensitive C-reactive protein (hs-CRP) were higher in left ventricular thickening (LVT)group, as compared with those in left ventricle normal group .Hemoglobin and estimated glomerular filtration rate ( eGFR) in LVT group were significantly lower than those in left ventricle normal group (P<0.05).Spearman rank correction indicated that LVH was positively correlated with serum uric acid and hs-CRP (r=0.283、0.327, all P<0.05).LVH was negatively correlated with hemoglobin and eGFR (r=-0.232, -0.186, all P<0.05).Multiple linear regression showed hs -CRP and hemoglobin correlated with LVH (β=0.235、-0.206, all P<0.05).Conclu-sion Inflammatory state and anemia were risk factors of LVH in LN patients .
