Research progress of PTEN pathway in anti-angiogenesis of tumors
10.3760/cma.j.issn.1009-9921.2013.10.020
- VernacularTitle:PTEN信号通路抑制肿瘤血管新生的研究进展
- Author:
Ning YANG
;
Jinzhong LIU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
PTEN;
Angiogenesis;
Vascular endothelial growth factor
- From:
Journal of Leukemia & Lymphoma
2013;22(10):634-636
- CountryChina
- Language:Chinese
-
Abstract:
PTEN is a dual protein/lipid phosphatase.As a negative regulator of PI3K/Akt pathway,PTEN not only plays an important role in multiple cellular functions such as cell metabolism,proliferation,cell-cycle progression,but also modulates angiogenesis via down-regulating PI3K-Akt-VEGF-HIF pathway in many tumors.In this review,the recent studies on the roles and mechanisms of PTEN in regulating tumorigenesis and angiogenesis are discussed to explore PTEN as a favorable prospect target in the treatment of angiogenesis.
