The Relationship between Orexin A and Respiratory Drive in Patients with Chronic Obstructive Pulmonary Disease
10.3969/j.issn.0253-9896.2014.08.019
- VernacularTitle:食欲素A与慢性阻塞性肺疾病患者呼吸中枢驱动的相关性研究
- Author:
Yong QIN
;
Feng LI
;
Tian ZHAO
- Publication Type:Journal Article
- Keywords:
pulmonary disease,chronic obstructive;
respiratory function tests;
respiratory center;
orexin-A
- From:
Tianjin Medical Journal
2014;(8):802-804
- CountryChina
- Language:Chinese
-
Abstract:
Obejective To explore the correlation of Orexin A and respiratory drive in chronic obstructive pulmo-nary disease (COPD) patients. Methods Pulmonary function was tested in 30 stable COPD patients and 20 normal healthy adults. Plasma orexin A level was measured with a radioimmunoassay kit. The correlation of Orexin A with BMI, age, BDI, FEV1, FVC, FEV1/FVC, MEP, MIP, P0.1 in COPD patients was analyzed. Results Plasma Orexin A levels in patients with COPD group(1.87±0.43)ng/L was higher than those in the control group(1.49±0.19)ng/L, P<0.01. Plasma Orexin A lev-els in patients with COPD correlated negatively with FEV1(r=-0.389,P < 0.05),and correlated positively with P0.1(r=0.728,P<0.01). Conclusion Plasma orexin A in COPD patients increased which may be caused by smoking and hyper-capnia. Orexin A may play a crucial role in regulating respiratory drive in COPD patients.
