Effect of Creatine Phosphate Sodium on Postoperative Fatigue in Gastric Carcinoma Patients
10.3969/j.issn.0253-9896.2014.08.028
- VernacularTitle:磷酸肌酸钠治疗胃癌手术后疲劳综合征的效果观察
- Author:
Xixia XU
;
Bibo TAN
;
Jingmiao WEI
;
Min WANG
;
Lingling WANG
;
Yong LI
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
postoperative complications;
treatment outcome;
creatine phosphate sodium;
postop-erative fatigue syndrome
- From:
Tianjin Medical Journal
2014;(8):830-833
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of creatine phosphate sodium on postoperative fatigue syndrome (POFS) in gastric carcinoma patients. Methods Nighty cases of radical resection in gastric cancer were randomly divided into control group (n=45) and treatment group (n=45).Normal saline (100 mL) and phosphocreatine sodium (2 g) was admin-istrated intravenously after anaesthesia induction in treatment group while only normal saline was given in control group . After operation, the two groups of patients were all treated with enteral and parenteral nutrition. General performance was ob-served in both groups. Fatigue score (VAS score) was measured on the day before the operation,the first,third and fifth day after operation. Body weight, triceps skinfold thickness (TSF), mid upper arm circumference (AMC), plasma total protein (TP), plasma albumin (ALB) and prealbumin (PA) were examined at the same time. Results The total effective rate of the control group and the study group were 73.3%and 95.6%respectively and the difference was of statistically significant. Fa-tigue scores (VAS score) was significantly difference in both groups pre- and post-operation time points, also between 2 groups. Body mass, TSF and AMC in time points postoperation were all lower than those in the time point of preoperation. TP, ALB and PA of two groups in postoperative time points were significantly different compared with those in preoperative time point. The above indexes were all decreased with postoperation time, and these indexes in treatment group were signifi-cantly better than those in control group. Conclusion Creatine phosphate sodium can alleviate postoperative fatigue, im-prove nutritious status and promote early rehabilitation of patients.
