Meta-Analysis of Effect of Continuous Renal Replacement Therapy to Severe Acute Pancreatitis
10.3969/j.issn.0253-9896.2014.08.029
- VernacularTitle:连续性肾脏替代治疗对重度急性胰腺炎疗效的Meta分析
- Author:
Zhe WANG
;
Fang WEI
;
Haiyan CHEN
;
Haibo YU
;
Ruining ZHANG
;
Zhi LU
;
Aili JIANG
- Publication Type:Journal Article
- Keywords:
pancreatitis;
renal replacement therapy;
prognosis;
Meta-analysis;
amylases;
C-reactive protein;
severe acute pancreatitis;
continuous renal replacement therapy
- From:
Tianjin Medical Journal
2014;(8):834-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of continuous renal replacement therapy (CRRT) on severe acute pancre-atitis (SAP). Methods According to the collaborative search strategy, MEDLINE (1966-2013.9), Embase(1974-2013.9), Chinese Wanfang database(1996-2013.9), CNKI(1979-2013.9) and the clinical control test database of Cochrane Library were searched.Published and unpublished literature and meeting summary were searched manually.Quality assessment and data extraction were conducted by two independent investigators. Meta-analysis was performed using RevMan 5.2. Results A total of 15 reports were identified which met the inclusion criteria, in which include data of 652 patients.Com-pared with control group, serum amylase decreased in CRRT group (WMD=-140.76, 95%CI was-212.42 to-69.11, P=0.000 1). Mediators of inflammatory mediators were scavenged effectively and APACHEⅡscore decreased in CRRT group (WMD=-2.97, 95%CI was-4.01 to-1.93, P<0.001). The overall survival rate was significantly higher in CRRT group than that in control group (RR=1.35, 95%CI 1.19-1.52, P<0.001). Conclusion Continuous renal replacement therapy could ef-fectively improve the survival rate of patients with severe acute pancreatitis.
