Neonatal Cow’s Milk Protein Allergy with Sepsis Like Initial Symptom
10.3969/j.issn.0253-9896.2014.08.017
- VernacularTitle:以类脓毒症为首发症状的新生儿牛奶蛋白过敏
- Author:
Yang LIU
;
Shuang BA
;
Chen ZHANG
;
Lili SONG
;
Chao SUN
;
Dan WANG
;
Jing GUO
- Publication Type:Journal Article
- Keywords:
milk hypersensitivity;
sepsis;
infant,newborn;
diagnosis,differential;
cow’s milk protein allergy
- From:
Tianjin Medical Journal
2014;(8):796-798
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the diagnosis and treatment in neonatal cow’s milk protein allergy (CMPA) with sepsis like initial symptom. Methods CMPA patients with the sepsis like initial symptom (n=10) were selected in our hospital from July 2009 to December 2013. History data, clinical manifestation, laboratory results and the treatment outcome of them were retrospectively analyzed. Results Among these 10 cases, 6 have family history of allergy. Main clinical mani-festations include skin, gastrointestinal symptoms and 1 case of anaphylactic shock. IgE mediated 6 cases with acidophilic cells count of (1.40±0.17)×109/L (5%); The rest 4 cases were not mediated by IgE, with acidophilic cells count of (0.71± 0.08)×109/L (0.02-0.03). Blood cultures were all negative;Blood leukocyte count is (24.5±3.3)×109/L;Rod nucleus granulo-cyte/neutrophils count is (0.161±0.035) ×109/L;The platelet count is (655±39)×109/L;Blood interleukin (IL)-6 is 0.31-0.93μg/L;C reactive protein (CRP) is 85-144 mg/L. All 10 cases were with extensively hydrolyzed formular or amino acid formu-lar feeding. Then their clinical symptoms improved or disappeared significantly and the inflammatory indexes returned to nor-mal. Conclusion It is necessary to make the differential diagnosis between sepsis and neonatal CMPA,which is accompa-nied by increased platelet and acidophil. The most effective treatment of neonatal CMPA is hypoallergenic formular replace-ment therapy.
