Food protein-induced enterocolitis syndrome caused by cow's milk protein allergy in an infant：case report and review of literature
10.3969/j.issn.1000-3606.2014.11.018
- VernacularTitle:牛奶蛋白过敏致婴儿食物诱导性小肠结肠炎综合征1例报告
- Author:
Tiefu FANG
;
Min YANG
;
Sitang GONG
;
Peiyu CHEN
;
Lanlan GENG
;
Zhaohui XU
;
Cuiping LIANG
;
Huiwen LI
;
Waner HE
- Publication Type:Journal Article
- Keywords:
cow’s milk protein allergy;
food protein-induced enterocolitis syndrome;
infants
- From:
Journal of Clinical Pediatrics
2014;(11):1074-1077
- CountryChina
- Language:Chinese
-
Abstract:
To discuss clinical diagnosis and treatment of cow’s milk protein allergy and cow’s milk protein-induced FPIES (food protein induced enterocolitis syndrome). Methods We retrospectively analyzed clinical data of one infant with milk protein allergy-induced FPIES. Results A 67 days old female on mixed breast and formula feeding developed recurrent diarrhea, abdominal distension, vomiting, mucousy and bloody stools, feeding dififculty, anemia, and failure to thrive since 2 weeks after birth. Laboratory studies showed anemia, increased CRP level and elevation of peripheral white blood count and eosinophil proportion. Milk-speciifc IgE was negative. She was previously hospitalized 4 times, all with admitting diagnosis of“necrotizing enterocolitis”. We treated her with milk protein elimination for 4 weeks and all symptoms were resolved. Milk protein re-challenge test was positive, consistent with clinical features of cow’s milk protein allergy-induced infant FPIES. Conclusions Cow’s milk protein allergy and cow’s milk protein-induced FPIES can present with non-speciifc and variable clinical symptoms and signs, and should be considered in the differential diagnosis.
