Association of MDR1 gene C3435T and T129C polymorphism in childhood refractory epilepsy
10.3969/j.issn.1000-3606.2014.11.003
- VernacularTitle:多药耐药基因1的C3435T、T129C多态性与儿童难治性癫痫的相关性
- Author:
Li GAO
;
Yan LI
;
Qiaofang HOU
;
Yanping LIU
;
Yan WANG
;
Liu YANG
;
Yan SUN
;
Yuanning MA
;
Feiyang ZHENG
- Publication Type:Journal Article
- Keywords:
multi-drug resistant 1 (gene);
single nucleotide polymorphism;
refractory epilepsy;
child
- From:
Journal of Clinical Pediatrics
2014;(11):1008-1012
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between multi-drug resistant 1 (MDR1) gene C3435T and T129C polymorphism with refractory epilepsy in children. Methods A total of 260 children including 60 refractory epilepsy, 100 drug-responsive epilepsy, and 100 healthy children were enrolled. The genotypes for MDR1 polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis.The distribution of genotypes and allele frequencies of the three groups were compared. Results The distribution of TT/TC/CC genotypes and T/C allele frequencies of C3435T showed no signiifcant difference between drug-resistant patients and drug-responsive patients or normal control group (P>0.05). Drug-resistant patients were more likely to have the TC genotype and the C allele at T129C when compared with the drug-responsive patients and the normal control group (P<0.05). Conclusions T129C polymorphism of the MDR1 gene was associated with refractory epilepsy in children.
