Research progress of fecal and urinary biomarkers for early diagnosis of neonatal necrotizing enterocolitis
- VernacularTitle:粪便及尿液生物标记物用于早期诊断新生儿坏死性小肠结肠炎研究进展
- Author:
Lijuan LUO
;
Luquan LI
- Publication Type:Journal Article
- Keywords:
necrotizing enterocolitis;
neonate;
biomarker;
noninvasive measurement
- From:
Journal of Clinical Pediatrics
2014;(11):1089-1092
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis (NEC) is the most common severe gastrointestinal emergency in neonatal period. Searching biomarkers to identify infants at greatest risk of developing NEC might be of importance for early diagnosis, effective treatment and better prognosis of NEC. Biomarkers from stool and urine attract great attention due to non-invasiveness and easy availability of fecal and urinary sampling. This article reviews the latest research progress of non-invasive biomarkers including intestinal fatty acid binding protein, serum amyloid A, complement C3a and C5a in urine;fecal lactoferrin, intestinal bacteria spectrum, fecal calprotectin, S100A12 and high mobility group box-1 protein.
