The molecular basis of myelodysplastic syndromes: current state and enlightenment
10.3760/cma.j.issn.1009-9921.2014.09.001
- VernacularTitle:骨髓增生异常综合征的分子生物学研究:现况与启示
- Author:
Zhijian XIAO
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndromes;
Gene mutation;
Diagnosis;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2014;23(9):513-514
- CountryChina
- Language:Chinese
-
Abstract:
The molecular basis of myelodysplastic syndromes (MDS) is revealed by whole genome sequencing or targeted gene sequencing in several large cohort of patients with MDS.About 90 ％ of MDS patients carry ≥ 1 oncogenic mutations,the consistently mutated genes are SF3B1,TET2,SRSF2,ASXL1,DNMT3A and RUNX1.The further studies of clonal architecture of MDS and the functions of the involved genes might considerably improve prognostication of MDS and more generally clinical decision-making in this field.
