Recent advances of aberrant expression of nucleophosmin in acute leukemia
10.3760/cma.j.issn.1009-9921.2014.12.015
- VernacularTitle:急性白血病中核仁磷酸蛋白异常表达的研究进展
- Author:
Lingyan WANG
- Publication Type:Journal Article
- Keywords:
Leukemia,acute;
Nucleophosmin
- From:
Journal of Leukemia & Lymphoma
2014;23(12):754-757
- CountryChina
- Language:Chinese
-
Abstract:
Nucleophosmin (NPM) is regularly identified as multifunctional nuclear protein which is widely expressed in different kinds of cells.NPM is identified not only as a potential regulator for cell proliferation,but also as an important player in tumor genesis procession.Aberrant expression of NPM,such as over-expression,rearrangement and mutation could lead to malignant transformation in solid tumor and leukemia cells.Over-expression of NPM had been detected as a poor prognostic factor and was related to drug-resistance development.It is reported that rearrangement of NPM gene played an important role in acute promyelocytic leukemia (APL,M3),myelodysplastic syndrome (MDS) and lymphoma.As the main molecular event in AML,NPM1 mutation occurred in kinds of subtypes of AML,which predicted a different prognosis.The aberrant expression of NPM in acute leukemia was reviewed.
