Effect of budesonide and doxofylline on patients with moderate persistent asthma

VernacularTitle:吸入激素联合口服缓释茶碱控制中度持续哮喘的观察
Author: Zhuochang CHEN ; Juanjuan DING ; Haoyu QIAN ; Xianghua LIN ; Keqing FENG ; Jing WANG
Publication Type:Journal Article
Keywords: Asthma; Doxofylline; Budesonide
From: The Journal of Practical Medicine 2014;(24):4015-4017
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of budesonide/doxofylline on patients with persistent asthma. Methods Sixty patients with moderate asthma were randomly divided into treatment group and control group. Patients in treatment group accepted the inhalation budesonide 400μg/d and doxofylline tablet 0.2 bid po but those in control group accepted the inhalation budesonide/formoterol 160/4.5μg bid. FeNO, sputum eosinophils, PEF and ACT scores were compared between two groups. Results PEF and ACT scores in treatment group were lower to those in control group (P<0.05), whereas the score of sputum eosinophils in treatment group was higher (P<0.05) one month later. There was no significant difference in FeNO between two groups (P>0.05). After three months, sputum eosinophils in treatment group were better than that in control group (P<0.05), whereas there was no significant difference in PEF, ACT scores and FeNO between two groups(P>0.05). Conclusion There is no significant difference in controlling asthma between budesonide/doxofylline and budesonide/formooterol