Efficacy of progesterone combined with Tiaojinghuoxue tablets treatment of amenorrhea induced by antipsychotic drug s
10.3969/j.issn.1006-5725.2014.24.051
- VernacularTitle:黄体酮联合调经活血片治疗抗精神病药物所致的药源性闭经的疗效观察
- Author:
Lu QIU
;
Qiong LI
;
Dan ZHU
- Publication Type:Journal Article
- Keywords:
Drug-induced amenorrhea;
Tiaojinghuoxue tablets;
Progesterone;
Antipsychotics;
Blood prolactin
- From:
The Journal of Practical Medicine
2014;(24):4018-4020
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of progesterone combined with Tiaojinghuoxue tablets in treating amenorrhea induced by antipsychotic drugs. Methods Total 100 patients were randomly divided into treatment group treated by progesterone combined with Tiaojinghuoxue tablets and progesterone group. The index including prolactin (PRL), luteinizing hormone (LH), estradiol (E2), endometrial thickness were measured before and after treatment in both groups . Also the clinical efficacy of the twogroups were compared. Results PRL, LH, E2, endometrial thickness and the recovery of menstrual flow rates in combination group were all better than the progesterone group, (P<0.05 or P<0.01). Cure rate in the combined group was 54.00%and the control group was 74.00%(P<0.05). Total effective rate of combined group was 90.00%and the control group was 80.00%(P>0.05). The rate of adverse reactions in combined group was 40.00%, less than 22.00%in progesterone group, (P<0.05). Conclusion The efficacy of progesterone combined withTiaojinghuoxue tablets is better than single progesterone treatment and have fewer adverse reactions in therpy antipsychotics drug induced amenorrhea.
