Relationship between thyroid autoantibodies and pregnancy outcome of infertility women after assisted reproductive technology：a systematic review
10.3969/j.issn.1006-5725.2014.24.048
- VernacularTitle:甲状腺自身抗体对不孕症妇女进行辅助生殖技术后妊娠结局影响的Meta分析
- Author:
Li ZHANG
;
Kai JIAO
- Publication Type:Journal Article
- Keywords:
Infertility;
Thyroid autoantibodies;
ART;
Miscarriage;
Adverse pregnancy outcome
- From:
The Journal of Practical Medicine
2014;(24):4011-4014
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between thyroid autoantibodies (ATA)and pregnancy outcome of infertility women after assisted reproductive technology (ART). Methods Relevant studies were identified by searching PubMed, Cochrane library, CNKI and CBM. Results 7 studies were appropriate for meta-analyses and total 4165 patiens were included. Meta analysis shows that the pregnancy rate difference between ATA positive patients and controls have no significance, but the miscarriage rate is greater significant between them. In the meta-analyses, the presence of thyroid antibodies was associated with an increased risk of miscarriage (OR 1.85, 95%CI 1.32~2.59), compared with the absence of thyroid antibodies. Conclusion Pregnant women with thyroid antibodies have an increased risk of complications, especially miscarriage. Future research,should focus on the treatment and thyroid disease on pregnancy outcome.
