Correlation Analysis between Expressions of p53, bcl-2 and caspase-3 in Patients with Non-Small Cell Lung Cancer
10.3969/j.issn.0253-9896.2014.07.013
- VernacularTitle:p53、bcl-2、caspase-3在非小细胞肺癌组织中的表达及相关性分析
- Author:
Lili ZHANG
;
Jie ZHANG
;
Lin ZHANG
;
Yang YU
;
Kun LIU
- Publication Type:Journal Article
- Keywords:
tumor suppressor protein p53;
proto-oncogene protein c-bcl-2;
caspase 3;
carcinoma,non-small-cell lung;
aged;
NSCLC
- From:
Tianjin Medical Journal
2014;(7):670-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of p53, bcl-2 and caspase-3 in elderly patients with advanced non-small cell lung cancer (NSCLC), and the clinical significance thereof. Methods The clinical data and paraffin tissue samples of 117 patients with NSCLC confirmed by postoperative pathology were collected. The expressions of p53, bcl-2 and caspase-3 protein in tissues of NSCLC were detected by immunohistochemical method. The correlation between the expres-sions of p53, bcl-2 and caspase-3 protein was analyzed, and the relationship between the expressions of p53, bcl-2 and cas-pase-3 protein and clinicopathological characteristics was explored. Results The positive expression rates of p53, bcl-2 and caspase-3 were 42.74%(50/117), 38.46%(45/117) and 36.75%(43/117) in tissue samples of NSCLC. The positive ex-pression rate of p53 was significantly higher in patients with poor differentiation, central type, lymph node metastasis and squamous carcinoma. The positive expression rate of bcl-2 was significantly higher in patients with high differentiation and lymph node metastasis. The positive expression rate of caspase-3 was significantly higher in patients with high differentia-tion and no lymph node metastasis. There was a positive correlation between expressions of bcl-2 and caspase-3 in NSCLC (r=0.262, P=0.003). Conclusion The expressions of p53, bcl-2 and caspase-3 may play important roles in development and progression of advanced NSCLC in elderly patients, which may serve as predicators for prognosis.
