Meaning of changes of interleukin-8 and C reactive protein levels after PCI in CHD patients
10.3969/j.issn.1008-0074.2014.05.22
- VernacularTitle:冠心病患者介入治疗后白介素-8和C反应蛋白水平变化的意义
- Author:
Zhifeng BAI
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Atherosclerosis;
Interleukin-8
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(5):550-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore interleukin (IL)-8 and C reactive protein (CRP) levels change after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) .Methods :A total of 90 CHD patients , who hospitalized in our hospital from Mar 2010 to Dec 2012 ,were selected .According to their therapeutic methods , they were divided into PCI group (n=70) and conservative treatment group (n=20) .Another 20 healthy people were regarded as healthy control group .Changes of IL-8 and C reactive protein (CRP ) concentrations before and within 20d after treatment were compared among three groups .Results :Compared with before treatment ,on 1d af-ter treatment ,there were significant reductions in levels of IL-8 [ (63.22 ± 13.10) pg/ml vs .(31.58 ± 9.10) pg/ml] and CRP [ (14.59 ± 6.13) mg/L vs .(9.61 ± 2.35) mg/L] in PCI group ,IL-8 was significantly lower than that of conservative treatment group [(50.18 ± 19.31) pg/ml] ,P<0.01 ;after 20d ,levels of IL-8 [(15.13 ± 5.22) pg/ml] and CRP [ (3.01 ± 0.76) mg/L] further declined in PCI group (P<0.05~ <0.01) ,and they were significantly lower than those of conservative treatment group [ (27.22 ± 14.69) pg/ml ,(5.46 ± 2.77) mg/L] , P<0.01 all , e-ven the IL-8 level of PCI group was not significant different from that of healthy control group [ (15.58 ± 4.10) pg/ml] , P>0.05. Conclusion:IL-8 and C reactive protein levels significantly reduce after PCI ,which can be treated as indexes evaluating PCI postoperative prognosis in CHD patients .
