Strategies for Generating Regulatory Dendritic Cells and the Clinical Application of Immune Tolerance
10.3969/j.issn.0253-9896.2014.07.030
- VernacularTitle:调节性树突状细胞的获取途径及其诱导免疫耐受的临床应用
- Author:
Yingxi LI
;
Dan CHEN
;
Keqiu LI
;
Guang LI
- Publication Type:Journal Article
- Keywords:
dendritic cells;
immune tolerance;
organ transplantation;
diabetes mellitus,type 1;
arthritis,rheumatoid;
T-lymphocytes;
regulatory dendritic cells
- From:
Tianjin Medical Journal
2014;(7):725-727
- CountryChina
- Language:Chinese
-
Abstract:
Dendritic cells (DCs) are potent antigen presenting cells with dual functions in immune response or im-mune tolerance. Regulatory dendritic cells (DCreg) have negative immunomodulation effects. They can inhibit T cell stimula-tory activity and induce immune tolerance. DCreg can be generated by the induction of drugs, cytokines and cell microenvi-ronment with different mechanisms. DCreg induced tolerance is of great clinical significance in organ transplantation and au-toimmune disease. Recently, several clinical trials have been conducted in type 1 diabetes and rheumatoid arthritis, with re-sults that emphasize the tolerance and safety of DCreg therapy. In this review, we will focus on the strategies for generating DCreg and the clinical application of immune tolerance.
