Progress in Pharmacological Mechanism for the Role of Fatty Acid in Reversal of Myocardial Toxicity of Local Anesthetics
10.3969/j.issn.0253-9896.2014.07.032
- VernacularTitle:脂肪酸逆转局麻药心肌毒性的药理机制研究进展
- Author:
Jing GAO
;
Chao LIU
- Publication Type:Journal Article
- Keywords:
fatty acids;
liposomes;
anesthetics,local;
nano-liposomes;
local anesthetics;
myocardial toxicity;
phar-macological mechanism
- From:
Tianjin Medical Journal
2014;(7):731-733
- CountryChina
- Language:Chinese
-
Abstract:
At present, there is no specific antidote for local anesthetic toxicity, which seriously hindered therapeutic efficts of clinical treatment. It is increasingly urgent for finding find the effective antidote to local anesthetic. This article at-tempts to interpret the molecular pharmacological mechanism from fat pool, energy metabolism, NO, ion channel and solubili-zation for the role of fatty acids in reversal of myocardial toxicity of local anesthetics. And the different characteristics of the structure and function of nano liposome and fat emulsion were compared.
