The experimental study of ideal resuscitation pressure for different ages of rats in uncontrolled hemorrhagic shock model
10.3760/cma.j.issn.1008-1372.2014.10.017
- VernacularTitle:不同年龄大鼠非控制失血性休克理想复苏压力的实验研究
- Author:
Zhifeng CHEN
;
Yuhang AI
- Publication Type:Journal Article
- Keywords:
Rats,Sprague-Dawley;
Resuscitation;
Disease models,animal;
Shock,hemorrhagic/therapy;
Blood pressure
- From:
Journal of Chinese Physician
2014;16(10):1370-1373
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages of rats.Methods Ninety-six rats were divided into 3 groups by ages (6 weeks,16 weeks and 12 months representing pre-adult,adult and elderly rats,respectively).Uncontrolled hemorrhagic-shock model was established in all rats.Then every group was divided into 4 groups by the different target pressures (untreated group,40 ～ 50 mmHg group,＞ 50 ～ 60 mmHg group,and ＞ 60 ～ 70 mmHg group).We recorded the survival time and 24 h survival rate of rats in each group and compared the blood gas analysis,blood lactate and hematocrit (Hct) level in each group at 90 min of establishing model.Results Different ages had different optimal recovery pressure.The optimal target resuscitation pressures for 6 weeks,16 weeks and 12 months rats were 40 ～50 mmHg,＞ 50 ～ 60 mmHg and ＞ 60 ～ 70 mmHg,respectively.Under the ideal pressure they had a better survival rate and lower blood lactate level (P ＜ 0.01 or P ＜ 0.05).Conclusious Hemorrhagic-shock rats at different ages have different ideal target resuscitation pressures during active hemorrhage.
