Roles of mitochondrial dysfunction in diabetes and diabetic cardiomyopathy
10.3760/cma.j.issn.1008-1372.2014.10.001
- VernacularTitle:线粒体功能障碍在糖尿病及其心肌病中的作用
- Author:
Yan XIONG
;
Weijin FANG
- Publication Type:Journal Article
- Keywords:
Mitochondria/pathology;
Diabetes mellitus;
Insulin resistance;
Diabetes complications
- From:
Journal of Chinese Physician
2014;16(10):1297-1302
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus is a common disease of serious harmful to human health,but its pathogenesis is not entirely clear.Mitochondria are the important organelles to generate energy in eukaryocytes,and play a pivotal role in the regulation of reactive oxygen species generation,intracellular calcium homeostasis,and apoptosis signal transduction.The possible causes of mitochondrial dysfunction include oxidative stress,Ca2+ disturbances,reduction of mitochondrial biosynthesis,opening of mitochondrial permeability transition pore,mitochondrial DNA mutations,and etc..Many studies demonstrate that mitochondrial dysfunction is associated with β-cell dysfunction of type 1 diabetes mellitus and insulin resistance of type 2 diabetes mellitus.Moreover,mitochondrial dysfunction plays important roles in the development of diabetic cardiomyopathy.This present article reviewed the current status of studies on the relationship of mitochondrial dysfunction and diabetes mellitus and diabetic cardiomyopathy.It is very important to understand and study mitochondrial dysfunction and its important roles in diabetes mellitus and diabetic cardiomyopathy in order to clarify the pathogenesis of diabetes mellitus and explore new approaches of prevention and treatment for diabetes mellitus.
