Expression and clinical significance of ubiquitin-specific protease 9X in pancreatic carcinoma of elderly patients
- VernacularTitle:老年患者胰腺癌组织中USP9X的表达及其临床意义
- Author:
Xiuzhong ZHANG
;
Weichao DING
;
Pengbo ZHANG
;
Chong ZHANG
;
Zeqiang REN
- Publication Type:Journal Article
- Keywords:
Ubiquitin-specific protease 9X;
Pancreatic carcinoma;
Immunohistochemical method;
Prognosis
- From:
Journal of Medical Postgraduates
2015;(1):67-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective There is close relationship between ubiquitin-specific protease 9X(USP9X) and the biological behav-ior of some tumor.The aim of this study is to investigate the expression and clinical significance of USP 9X in pancreatic carcinoma of elderly patients. Methods The expression of USP9X was detected in 30 pieces of surgically resected primary pancreatic carcinoma tissue and adjacent nontumorous pancreatic tissue of elderly patients by streptavidin -perosidase immunohistochemical method . Results The rate of USP9X positive expression was 56.7%, there was not positive expression in adjacent nontumorous pancreatic tissue .There was no relation between the expression of USP 9X with gender, age, the tumor positin, the tumor size and degree of differentiation (P>0.05), while it was significantly correlated with lymph node metastasis and TNM stages (P<0.05).By using Cox proportional haz-ards analysis, multivariable analysis revealed that TNM stages , lymph node metastasis and USP9X expression were independent risk factor(P<0.05). Conclusion The results indicated that USP9X may play a role in the pathogenesis and prognosis of pancreatic cancer of elderly patients .
