Recent advances of ABCG1 in cholesterol transport
- VernacularTitle:ABCG1在胆固醇转运中作用研究新进展
- Author:
Ting YANG
;
Sumeng WANG
;
Junjun WANG
- Publication Type:Journal Article
- Keywords:
ATP-binding cassette G1;
Cholesterol transport;
Atherosclerosis
- From:
Journal of Medical Postgraduates
2015;(1):89-93
- CountryChina
- Language:Chinese
-
Abstract:
Cholesterol is considered to play a critical role in cellular activities .However , high level of peripheral cholesterol is a risk factor for atherosclerosis .ABCG1 is a new member of ABCG1 transporter family, which is involved in cholesterol reverse transport . ABCG1 plays a crucial role in maintaining intracellular sterol homeostasis , but its exact function in atherosclerosis is still unclear .Eluci-dation of the mechanisms of ABCG 1 in intracellular sterol flux will provide important information that may link ABCG 1 to diseases of dys-regulated tissue lipid homeostasis .This review focuses on recent advances of ABCG 1 and its roles in cholesterol transport .
