Research advances of the antioxidative activities of selective estrogen receptor modulators
- VernacularTitle:选择性雌激素受体调节剂抗氧化作用的研究进展
- Author:
Li GUO
;
Jingwei ZHOU
;
Bing YAO
- Publication Type:Journal Article
- Keywords:
Selective estrogen receptor modulators;
Antioxidation;
Free radical
- From:
Journal of Medical Postgraduates
2015;(1):94-97
- CountryChina
- Language:Chinese
-
Abstract:
Selective estrogen receptor modulators (SERMs) is a class of estrogen-like non-steroid compounds that are able to bind to steroid hormone receptors .They can act as estrogen receptor agonist or antagonist depending on the target tissue and hormonal environment .Additionally , SERMs play an antioxidant role by scavenging oxygen free redicals , inhibiting lipid peroxidation , adjusting the level of NO and NOS , inhibiting mitochondrial permeability transition , improving the metabolism of free fatty acids in the mitochon-drial and regulating non-genomic transcription pathway .
