Roles of the CXCL12-CXCR4/CXCR7 chemokine axis in colorectal carcinoma
- VernacularTitle:CXCL12-CXCR4／CXCR7趋化轴在结直肠癌中作用的研究进展
- Author:
Dan YANG
;
Xiaoyuan CHU
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
CXCL12;
CXCR4;
CXCR7
- From:
Journal of Medical Postgraduates
2015;(1):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal carcinoma ( CRC ) is one of the malignant tumors with the highest morbidity and mortality rates in the world.The invasion and metastasis of CRC are the major reasons for treatment failure and death .It was believed that CXCR 4 was the exclusive receptor for CXCL12.However, recent studies have identified CXCR7 as a second receptor for CXCL12.Both chemokine ax-es of CXCL12/CXCR4 and CXCL12/CXCR7 closely correlate with the proliferation , migration, adhesion of tumor cells and the forma-tion of tumor-associated vessels in CRC , which may become new significant targets for anti-cancer and anti-metastatic treatment of CRC.
