Functions of semaphorin 4D in tumor progression
10.3969/j.issn.1000-8179.20141558
- VernacularTitle:轴突导向蛋白4D在肿瘤进展中的作用
- Author:
Lei ZHANG
;
Ying CHEN
;
Ke WANG
- Publication Type:Journal Article
- Keywords:
SEMA4D;
axon guidance;
tumor;
immunoregulation;
angiogenesis
- From:
Chinese Journal of Clinical Oncology
2015;(3):185-189
- CountryChina
- Language:Chinese
-
Abstract:
Semaphorin 4D (SEMA4D), also known as CD100, is a protein that belongs to class IV semaphorin. Its physiologic role in the nervous system has been extensively explored. However, the roles of SEMA4D have extended beyond the traditionally studied territories. Collective data proved that SEMA4D has an important role in the regulation of immune system, angiogenesis, and tumorigenesis, among others. Specifically, SEMA4D enhanced the angiogenesis in malignant diseases. This review summarized the latest progression in the research on SEMA4D, including the structure, receptors, mechanism, and biological functions in tumor angiogenesis and progression.
