The Effect of Lovastatin Combined with Calcitonin on Fracture Repair in Osteoporotic Rats
10.3969/j.issn.0253-9896.2014.03.014
- VernacularTitle:洛伐他汀联合降钙素治疗骨质疏松大鼠骨折的效果分析
- Author:
Guolong CAO
;
Xiaopo LIU
;
Yunbo FENG
;
Faming TIAN
- Publication Type:Journal Article
- Keywords:
osteoporosis;
fractures,bone;
lovastatin;
calcitonin;
bone density;
disease models,animal
- From:
Tianjin Medical Journal
2014;(3):238-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of lovastatin alone or combined with calcitonin on fracture repair in osteoporotic rats. Methods Forty 4-month-old female SD rats were randomized into 5 groups(8 rats in each group):normal fractured group (A), osteoporotic fractured group (B), lovastatin treatment group(C), calcitonin treatment group (D) and lovastatin combined with calcitonin treatment group. All rats except group A received bilateral ovariectomy. The midshaft femur fracture model was established in all rats 8 weeks after operation. The serum level of procollagen amino-terminal propeptide (PINP) was assessed by ELISA. X-ray and bone mineral density detection was used to observe the fracture healing process. The maximal loading of femoral fractures was analyzed by biomechanical method. Results (1) The serum level of PINP was significantly lower in group A than that of other groups. There was a significantly higher level of PINP in group C and group E than that of group B, and the level of PINP was significantly lower in group D than that of group C. (2) The X-ray showed more progressed fracture healing in group A and group E. The accordingly score indicated that there was a markedly higher score in groups A and group E compared to that of other three groups. (3) There was a highest bone mineral density in the full-length and in the middle of femur bone in group A, followed by group E, group D and group C. The lowest bone mineral density was found in group B. (4) The biomechanical test showed that the maximal loading in femur fracture side was significantly higher in group A than that of other four groups, in which it was higher in group E than that of group B. Conclusion The osteoporosis decreased bone mass and delayed fracture healing process in rat model. The treatment of lovastatin combined with calcitonin showed more positive effect on preventing bone loss and promoting fracture repair than lovastatin alone.
