The Correlation between Serum Amyloid A and Disease Activity in Patients with Rheumatoid Arthritis
10.3969/j.issn.0253-9896.2014.03.016
- VernacularTitle:血清淀粉样蛋白A与类风湿关节炎疾病活动度的相关性研究
- Author:
Chen SHEN
;
Yun MU
;
Na LIU
;
Donghong XING
;
Chengcheng HONG
;
Wei WEI
;
Fang ZHENG
- Publication Type:Journal Article
- Keywords:
arthritis,rheumatoid;
serum amyloid A protein;
blood sedimentation;
C-reactive protein;
lupus erythe-matosus,systemic;
osteoarthritis;
disease activity
- From:
Tianjin Medical Journal
2014;(3):245-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum amyloid A (SAA) and disease activity (DAS28) in patients with rheumatoid arthritis (RA). Methods Forty-four patients with RA, 35 patients with systemic lupus erythe-matosus (SLE), 18 patients with osteoarthritis (OA) and 30 healthy controls (HC) were enrolled in this study. The levels of SAA were measured by ELISA. Erythrocyte sedimentation rate (ESR) was measured by the Westergren method. The value of serum C reactive protein (CRP) was examined by immunonephelometry assay. The correlation between SAA and DAS 28, ESR and CRP was assessed, respectively. Results The SAA levels were significantly higher in RA group than those of SLE, OA, and HC groups (P<0.05). The serum ESR and CRP levels were both higher in RA group than those of OA and HC groups (P>0.05), but there was no significant difference between RA group and SLE group. There was positive correlation between SAA and DAS28, ESR, and CRP levels (rs=0.790, P<0.001;rs=0.674, P<0.001;rs=0.679, P=0.004), respective-ly. Conclusion SAA may be a new serological marker to assess disease activity in RA.
