Effects of Sodium Cantharidinate and Vitamin B6 Injection on Plasma D-dimer Level in Patients of Advanced Esophageal Cancer after Chemotherapy
10.3969/j.issn.0253-9896.2014.03.019
- VernacularTitle:艾易舒对食管癌患者化疗后血浆D-二聚体水平的影响
- Author:
Hui ZHU
;
Haiyan ZHANG
;
Ming HE
;
Xin CHEN
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms;
carcinoma;
antineoplastic combined chemotherapy protocols;
D-dimer;
sodium cantharidinate
- From:
Tianjin Medical Journal
2014;(3):254-256
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of sodium cantharidinate and vitamin B6 injection on plasma D-dimer level in patients of advanced esophageal cancer after chemotherapy and the relationship between plasma D-dimer level and clinical pathological parameters thereof. Methods Fifty-eight patients with advanced esophageal cancer confirmed by path-ological examination were randomly divided into two groups. Twenty-nine patients (experimental group) received chemother-apy (PF chemotherapy) combined with sodium cantharidinate and vitamin B6 (0.5 mg once daily). Twenty-nine patients (con-trol group) received same volume of saline. And there were 20 healthy volunteers as the normal control. The plasma D-dimer level was determined one day before the first cycle of chemotherapy and the third cycle of treatment. Results The plasma D-dimer level was significantly higher before chemotherapy in patients with advanced esophageal cancer than that in normal control group (P<0.05). There were no significant differences in plasma D-dimer level between patient gender, age, clinical stage and pathological levels. The D-dimer level was significantly down-regulated after chemotherapy. The D-dimer level was significantly lower in experimental group than that in control group (P<0.05). The incidences of digestive and hemato-logical adverse reactions were much lower in experimental group than those in control group. Conclusion The elevated plasma D-dimer level was found in patients with advanced esophageal cancer, and which was down-regulated by chemother-apy. The chemotherapy of sodium cantharidinate and vitamin B6 can further reduce the D-dimer level, and relieve the ad-verse reactions of chemotherapy.
