Association of endothelial nitric oxide synthase gene polymorphisms and avascular necrosis of femoral head
10.3760/cma.j.issn.1008-1372.2014.11.020
- VernacularTitle:内皮细胞一氧化氮合成酶基因多态性和缺血性股骨头坏死的相关性研究
- Author:
Liwen ZHENG
;
Wanchun WANG
;
Jiangdong NI
;
Zhihong LI
- Publication Type:Journal Article
- Keywords:
Polymorphism,genetic;
Endothelial cells/enzymology;
Nitric oxide synthase/genetics;
Ischemia;
Femur head necrosis/genetics
- From:
Journal of Chinese Physician
2014;16(11):1524-1529
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of endothelial nitric oxide synthase (eNOS) polymorphisms and avascular necrosis of femoral head (ANFH),to explore possible relationship between the ANFH incidence and 27-bp repeat polymorphism in intron 4 and G894T polymorphism in exon 7.Methods Totally 125 atraumatic ANFH patients and 126 healthy controls without hip trauma history were enrolled.Gene polymorphisms in 27-bp repeat polymorphism in intron 4 and G894T polymorphism in exon 7 were determined.Medical history was collected for etiology analysis.Results In between-group comparison,the frequency of b/a genotype intron 4 in ANFH group was significantly higher than that in healthy control group [19/125 (15.2％) vs 6/126 (4.8％),P =0.0001,OR =4.501],and the result of G/T genotype exon 7 in the ANFH group also indicated a statistical significance with the healthy control group [30/125 (24.0％) vs 17/126 (13.5％),P =0.0094,OR =3.804].In subgroup analysis,genotype b/a and G/T were especially higher in the idiopathic group than that in the healthy control group.Conclusions eNOS gene polymorphisms might be a risk factor of ANFH,there is underlying relevance of eNOS and the disease.Both 27-bp repeat polymorphism in intron 4 and G894T polymorphism in exon 7 are associated with ANFH incidence.
